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Pim-1 kinase inhibitor 8

CAS No. 916038-47-6

Pim-1 kinase inhibitor 8( —— )

Catalog No. M37329 CAS No. 916038-47-6

Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Pim-1 kinase inhibitor 8
  • Note
    Research use only, not for human use.
  • Brief Description
    Pim-1 kinase inhibitor 8 is a potent Pim-1 kinase inhibitor with anticancer activity and can effectively inhibit cell migration.
  • Description
    Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC50s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    PKC | Pim
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    916038-47-6
  • Formula Weight
    275.3
  • Molecular Formula
    C14H17N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (454.05 mM; Ultrasonic )
  • SMILES
    N#CC1=C(N=C(C=C1C)C)OCC(=O)N2CCOCC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shaban SM, et al. Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega. 2023 Nov 27;8(49):46922-46933.?
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